Genetic Variants of the L-Zagreb Mumps Vaccine Strain
Author Information
Author(s): Kosutic-Gulija Tanja, Forcic Dubravko, Šantak Maja, Ramljak Ana, Mateljak-Lukacevic Sanja, Mazuran Renata
Primary Institution: Institute of Immunology Inc, Zagreb, Croatia
Hypothesis
The genetic composition of the L-Zagreb mumps vaccine strain is heterogeneous and consists of multiple variants.
Conclusion
The L-Zagreb strain should be considered a single strain composed of at least two variant viral genomes.
Supporting Evidence
- Two major variants of the L-Zagreb strain were identified.
- Variant A is identical to the consensus sequence, while variant B differs in three nucleotide positions.
- The proportion of variants depends on the cell substrate used for viral replication.
Takeaway
The L-Zagreb mumps vaccine has different versions of the virus, but they are all part of the same strain.
Methodology
The study involved cloning and sequencing viral genome fragments to analyze genetic variations.
Limitations
The study's findings may not represent all L-Zagreb vaccine strains due to the specific samples analyzed.
Digital Object Identifier (DOI)
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