Cis-Regulatory Evolution of CCNB1IP1 Driving Gradual Increase of Cortical Size and Folding in primates
2024
How CCNB1IP1 Affects Primate Brain Size and Folding
publication
Author Information
Author(s): Hu Ting, Kong Yifan, Tan Yulian, Ma Pengcheng, Wang Jianhong, Sun Xuelian, Xiang Kun, Mao Bingyu, Wu Qingfeng, Yi Soojin V., Shi Lei
Primary Institution: Cold Spring Harbor Laboratory
Hypothesis
The study investigates the role of CCNB1IP1 in the evolution of neocortex size and folding in primates.
Conclusion
Changes in CCNB1IP1 expression may have contributed to the gradual evolution of the primate brain.
Supporting Evidence
- CCNB1IP1 expression has steadily increased over the course of primate brain evolution.
- CCNB1IP1 expression can cause an increase in neural progenitors through shortening G1 phase.
- The CCNB1IP1 knock-in mouse model exhibited traits associated with enhanced learning and memory abilities.
Takeaway
This study found that a gene called CCNB1IP1 helps make primate brains bigger and more folded, which is important for thinking.
Methodology
The study used tree shrew as an outgroup and a CCNB1IP1 knock-in mouse model to investigate gene expression effects.
Digital Object Identifier (DOI)
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