Homocysteine and Its Role in Behcet's Disease
Author Information
Author(s): Kartal Durmazlar Selda Pelin, Akgul Ahmet, Eskioglu Fatma
Primary Institution: Diskapi Yildirim Beyazit Education and Research Hospital, Ministry of Health Ankara
Hypothesis
Is elevated homocysteine associated with inflammation in Behcet's disease?
Conclusion
Homocysteine may contribute to the pathogenesis of Behcet's disease by inducing inflammation.
Supporting Evidence
- Hcy levels were significantly elevated in active Behcet's disease compared to inactive and healthy controls.
- Hcy was found to be the best predictor of TNF-α among other parameters.
- A significant positive correlation was found between serum Hcy and TNF-α levels.
- Patients with oral and genital ulcers had higher Hcy levels.
- Elevated Hcy levels were associated with increased disease activity.
Takeaway
This study found that high levels of homocysteine are linked to inflammation in patients with Behcet's disease, which could lead to more serious health issues.
Methodology
The study evaluated serum homocysteine levels in 70 patients with Behcet's disease and 33 healthy controls, measuring various inflammatory markers.
Potential Biases
Potential bias due to the selection of patients and exclusion criteria.
Limitations
The study's retrospective nature and exclusion of patients on medication may limit the findings.
Participant Demographics
70 patients (40 males, 30 females; mean age 33) and 33 healthy controls (17 males, 16 females; mean age 30).
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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