Susceptibility Genes for Familial Wilms Tumour
Author Information
Author(s): Rapley E A, Barfoot R, Bonaïti-Pellié C, Chompret A, Foulkes W, Perusinghe N, Reeve A, Royer-Pokora B, Schumacher V, Shelling A, Skeen J, Tourreil S de, Weirich A, Pritchard-Jones K, Stratton M R, Rahman N
Primary Institution: Institute of Cancer Research
Hypothesis
Are there additional susceptibility genes for familial Wilms tumour beyond WT1, FWT1, and FWT2?
Conclusion
The study suggests that there are likely additional familial Wilms tumour susceptibility genes yet to be identified.
Supporting Evidence
- Three loci have been implicated in familial Wilms tumour: WT1, FWT1, and FWT2.
- Two out of 19 families showed strong evidence against linkage at all three loci.
- Both families contained at least three cases of Wilms tumour.
Takeaway
Some families with Wilms tumour might have genes that make them more likely to get it, and we haven't found all those genes yet.
Methodology
Evaluation of 19 Wilms tumour families for genetic linkage at three loci.
Limitations
Only two families showed strong evidence against linkage, indicating limited data.
Participant Demographics
Families with multiple cases of Wilms tumour.
Digital Object Identifier (DOI)
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