ContDist: a tool for the analysis of quantitative gene and promoter properties
2009
ContDist: A Tool for Analyzing Gene and Promoter Properties
Sample size: 252
publication
Evidence: high
Author Information
Author(s): Hackenberg Michael, Lasso Gorka, Matthiesen Rune
Primary Institution: CIC bioGUNE
Hypothesis
Can a tool be developed to analyze quantitative features of gene and promoter regions?
Conclusion
ContDist is a new tool that effectively analyzes quantitative properties of gene and promoter regions, revealing significant biological insights.
Supporting Evidence
- ContDist includes approximately 200 quantitative features of gene and promoter regions for 7 commonly studied species.
- The tool confirmed recent findings about the differences in GC content between unmethylated and differentially methylated promoters.
- ContDist revealed new insights into the stiffness of DNA in differentially methylated promoters compared to unmethylated ones.
- Significant differences in the number of protein-protein interactions were found between housekeeping and tissue-specific genes.
Takeaway
ContDist is a computer program that helps scientists understand how genes work by looking at special parts of DNA called promoters.
Methodology
The tool analyzes gene lists using statistical tests like Kolmogorov-Smirnov and randomization tests to compare quantitative features.
Statistical Information
P-Value
2.13E-05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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