Expression of calcium-binding protein S100A2 in breast lesions
2000
S100A2 Protein in Breast Lesions
publication
Author Information
Author(s): Liu D, Rudland P S, Sibson D R, Platt-Higgins A, Barraclough R
Primary Institution: School of Biological Sciences, University of Liverpool
Hypothesis
The expression of S100A2 protein is associated with benign breast lesions and its loss is linked to malignant breast cells.
Conclusion
The study found that S100A2 is present in benign breast lesions but often absent in malignant breast cancer specimens.
Supporting Evidence
- S100A2 protein is expressed in normal human breast epithelium.
- S100A2 mRNA was found in all benign breast lesions examined.
- S100A2 mRNA was detectable in 37% of carcinoma in situ specimens.
- Less than 15% of carcinoma specimens showed S100A2 mRNA.
Takeaway
This study shows that a protein called S100A2 is found in healthy and benign breast tissue but is often missing in cancerous tissue.
Methodology
The study used PCR-based assays and in situ hybridization on histological sections of human breast specimens.
Digital Object Identifier (DOI)
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