Loss of Chromosome 10 in High-Grade Gliomas
Author Information
Author(s): Balesaria S, Brock C, Bower M, Clark J, Nicholson S K, Lewis P, de Sanctis S, Evans H, Peterson D, Mendoza N, Glaser M G, Newlands E S, Fisher R A
Primary Institution: Department of Cancer Medicine, Imperial College School of Medicine, Charing Cross Hospital, London, UK
Hypothesis
Is loss of chromosome 10 an independent prognostic factor in high-grade gliomas?
Conclusion
Loss of chromosome 10 is an independent, adverse prognostic variable in high-grade glioma.
Supporting Evidence
- 35% of patients with grade 3 tumors showed loss of chromosome 10.
- 59% of patients with grade 4 tumors showed loss of chromosome 10.
- There was a correlation between chromosome 10 loss and poorer performance status at presentation.
- Age at diagnosis was correlated with chromosome 10 loss.
Takeaway
This study found that losing part of chromosome 10 can make brain tumors worse and lead to shorter survival times.
Methodology
Fluorescent microsatellite markers were used to examine 83 patients with high-grade gliomas for loss of heterozygosity on chromosome 10.
Participant Demographics
34 patients with anaplastic astrocytoma (grade 3) and 49 with glioblastoma multiforme (grade 4).
Statistical Information
P-Value
0.004
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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