Risk Factors for Pancreatic Cancer
Author Information
Author(s): Silverman D T, Schiffman M, Everhart J, Goldstein A, Lillemoe K D, Swanson G M, Schwartz A G, Brown L M, Greenberg R S, Schoenberg J B, Pottern L M, Hoover R N, Fraumeni J F Jr
Primary Institution: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Hypothesis
What medical conditions and family history contribute to the risk of pancreatic cancer?
Conclusion
The study found that diabetes and cholecystectomy are significant risk factors for pancreatic cancer, while certain allergies may reduce risk.
Supporting Evidence
- Diabetes is a risk factor for pancreatic cancer.
- Cholecystectomy is associated with increased risk of pancreatic cancer.
- A family history of pancreatic cancer significantly increases risk.
- Hay fever is associated with a reduced risk of pancreatic cancer.
- No significant risk was found for those with a history of duodenal or gastric ulcers.
Takeaway
People with diabetes or who have had their gallbladder removed are more likely to get pancreatic cancer, while some allergies might help protect against it.
Methodology
A population-based case-control study interviewing 484 pancreatic cancer cases and 2099 controls.
Participant Demographics
Participants included cases of pancreatic cancer and matched controls from three areas in the USA.
Statistical Information
P-Value
0.016
Confidence Interval
0.9–1.6
Statistical Significance
p=0.016
Digital Object Identifier (DOI)
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