Effects of Hesperidin on Allergic Asthma in Mice
Author Information
Author(s): Kim Seung-Hyung, Kim Bok-Kyu, Lee Young-Cheol
Primary Institution: Institute of Traditional Medicine and Bioscience, Daejeon University
Hypothesis
Hesperidin may have antiasthmatic effects by inhibiting Th2 cytokines and eosinophil infiltration in a mouse model of allergic asthma.
Conclusion
Hesperidin effectively reduces airway inflammation and hyperresponsiveness in a mouse model of asthma by suppressing Th2 cytokines and eosinophil accumulation.
Supporting Evidence
- HPN-treated mice showed reduced eosinophil infiltration and airway inflammation.
- Th2 cytokines such as IL-5 and OVA-specific IgE levels were significantly decreased in HPN-treated groups.
- Histological analysis indicated less inflammatory cell infiltration in the lungs of HPN-treated mice.
Takeaway
Hesperidin, a natural compound found in citrus fruits, helps reduce asthma symptoms in mice by lowering inflammation and allergic reactions.
Methodology
BALB/c mice were sensitized to ovalbumin and treated with hesperidin to assess its effects on airway hyperresponsiveness and inflammation.
Limitations
The study was conducted only in mice, and results may not directly translate to humans.
Participant Demographics
Five-week-old female BALB/c mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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