Prognostically orientated multimodality treatment including surgery for selected patients of small-cell lung cancer patients stages IB to IIIB: long-term results of a phase II trial
1999

Effective Treatment for Small-Cell Lung Cancer

Sample size: 46 publication Evidence: moderate

Author Information

Author(s): Eberhardt W, Stamatis G, Stuschke M, Wilke H, Müller M R, Kolks S, Flasshove M, Schütte J, Stahl M, Schlenger L, Budach V, Greschuchna D, Stüben G, Teschler H, Sack H, Seeber S

Primary Institution: West German Cancer Center, University of Essen Medical School

Hypothesis

Can a multimodality treatment approach improve outcomes for small-cell lung cancer patients?

Conclusion

The multimodality treatment including surgery was highly effective, showing significant long-term survival rates in patients with small-cell lung cancer.

Supporting Evidence

  • 94% of patients showed an objective response to the treatment.
  • 72% of patients planned for surgery were completely resected.
  • The median survival for all patients was 36 months.
  • The 5-year survival rate for all patients was 46%.
  • R0 patients had a median survival of 68 months.

Takeaway

Doctors used a combination of treatments to help patients with a type of lung cancer, and many of them lived much longer after the treatment.

Methodology

Patients received a combination of chemotherapy, radiation, and surgery based on their cancer stage.

Limitations

The study had a small sample size and limited follow-up for some patients.

Participant Demographics

Patients included those with small-cell lung cancer stages IB to IIIB.

Digital Object Identifier (DOI)

10.1038/sj.bjc.6690830

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