The association between CD2+ peripheral blood lymphocyte subsets and the relapse of bladder cancer in prophylactically BCG-treated patients
1999

CD2+ Lymphocyte Subsets and Bladder Cancer Relapse

publication

Author Information

Author(s): Reyes E, Carballido J, Manzano L, Moltó L, Olivier C, Alvarez-Mon M

Primary Institution: University Hospital ‘Principe de Asturias’, University of Alcalá, Madrid, Spain

Hypothesis

Are there differences in T-lymphocyte subsets and their response in bladder cancer patients treated with BCG based on their clinical outcomes?

Conclusion

The study found differences in T-lymphocyte subset distribution and activation in bladder cancer patients treated with BCG, which may relate to their clinical response.

Supporting Evidence

  • Different T-lymphocyte subset distributions were found in patients based on their clinical response to BCG treatment.
  • The study observed a transitory variation in T-lymphocyte subset distribution after BCG instillations.

Takeaway

This study looked at how certain immune cells behave in bladder cancer patients who received a specific treatment, finding that those who did well had different immune responses than those who had a relapse.

Methodology

The study investigated T-lymphocyte subset distribution and proliferative responses in bladder cancer patients treated with BCG.

Digital Object Identifier (DOI)

10.1038/sj.bjc.6690185

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