A change in microsatellite instability caused by cisplatin-based chemotherapy of ovarian cancer
2001
Changes in Microsatellite Instability in Ovarian Cancer After Chemotherapy
Sample size: 24
publication
Evidence: moderate
Author Information
Author(s): Watanabe Y, Koi M, Hemmi H, Hoshai H, Noda K
Primary Institution: Kinki University School of Medicine
Hypothesis
How does cisplatin-based chemotherapy affect microsatellite instability in ovarian cancer?
Conclusion
The study found that chemotherapy can change the microsatellite instability of ovarian cancer tumors, affecting their genetic stability.
Supporting Evidence
- 37.5% of primary tumors showed microsatellite instability.
- 72.5% of primary tumors were microsatellite stable.
- All cases with microsatellite stability in primary tumors exhibited instability in residual tumors after chemotherapy.
- 73.3% of cases changing from stable to unstable had a loss of hMLH1 expression.
Takeaway
When women with ovarian cancer get treated with certain chemotherapy drugs, the way their cancer's DNA changes can also change.
Methodology
The study compared microsatellite instability and hMSH2/hMLH1 expression in primary and residual tumors after chemotherapy.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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