Complete Remission in Mantle-Cell Lymphoma After Splenic Irradiation
Author Information
Author(s): Filippi Andrea Riccardo, Franco Pierfrancesco, Galliano Marco, Ricardi Umberto
Primary Institution: University of Torino, Ospedale S. Giovanni Battista, Torino, Italy
Hypothesis
Can splenic irradiation lead to complete remission in patients with Mantle-Cell Lymphoma?
Conclusion
The patient achieved complete remission in peripheral blood after receiving splenic irradiation.
Supporting Evidence
- The patient had a complete remission in peripheral blood after splenic irradiation.
- Splenic irradiation has been used as palliative treatment in various lymphoproliferative disorders.
- The presence of 11q22-23 deletion and ATM inactivation may predict radiation response.
Takeaway
A 90-year-old woman with a type of blood cancer got better after receiving radiation treatment on her spleen.
Methodology
The patient received 15 Gy of radiation in 10 fractions over 2 weeks to the spleen.
Limitations
Only one patient was studied, and a second bone marrow biopsy was not performed due to the patient's age and performance status.
Participant Demographics
One 90-year-old female patient with Mantle-Cell Lymphoma.
Digital Object Identifier (DOI)
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