Expression of individual lamins in basal cell carcinomas of the skin
2001
Lamin Expression in Basal Cell Carcinomas
Sample size: 16
publication
Author Information
Author(s): Venables R S, McLean S, Luny D, Moteleb E, Morley S, Quinlan R A, Lane E B, Hutchison C J
Primary Institution: University of Dundee
Hypothesis
Lamin A has a negative influence on cell proliferation and its down regulation may be a requisite of tumour progression.
Conclusion
The absence of lamin A is correlated with rapid tumor growth, while the absence of lamin C is associated with slower growth.
Supporting Evidence
- Lamin A was absent from all basal epithelial cells in normal skin.
- Lamin C was not expressed in quiescent basal epithelial cells.
- Lamin B1 was expressed in all epithelial cells but not in dermal fibroblasts.
- Lamin B2 was expressed in all cell types in normal skin.
- 9 out of 10 lamin A negative tumors were highly proliferative.
Takeaway
This study looked at how certain proteins in skin cells relate to cancer growth, finding that less of one protein means the cancer might grow faster.
Methodology
Lamin expression was studied using type specific anti-lamin antibodies and immunofluorescence on frozen tissue samples.
Digital Object Identifier (DOI)
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