Resistance to chemotherapy: new treatments and novel insights into an old problem
2008
Resistance to Chemotherapy: New Treatments and Insights
publication
Evidence: moderate
Author Information
Author(s): Raguz S, Yagüe E
Primary Institution: Imperial College Faculty of Medicine
Hypothesis
The ability to acquire drug resistance arises early during the tumorigenesis process.
Conclusion
Drug resistance can develop before full malignant transformation, indicating it is an intrinsic part of the tumorigenesis process.
Supporting Evidence
- Drug resistance mechanisms can arise early in the tumorigenic process.
- Minimally transformed cells can develop drug resistance before full malignant transformation.
- Resistance to therapies like imatinib and trastuzumab highlights the ongoing challenge in cancer treatment.
Takeaway
Cancer cells can learn to resist treatment even before they become fully cancerous, making it harder to treat them later.
Limitations
The findings need to be confirmed in other cancer models and with different drugs.
Digital Object Identifier (DOI)
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