Dipyridamole potentiates the in vitro activity of MTA (LY231514) by inhibition of thymidine transport
2000
Dipyridamole Enhances Cancer Drug Effectiveness
publication
Author Information
Author(s): Smith P G, Marshman E, Newell D R, Curtin N J
Primary Institution: Cancer Research Unit, University of Newcastle upon Tyne
Hypothesis
Can dipyridamole enhance the effectiveness of the cancer drug LY231514 by inhibiting thymidine transport?
Conclusion
Dipyridamole prevents the reversal of growth inhibition caused by LY231514 by inhibiting thymidine transport.
Supporting Evidence
- Dipyridamole inhibited thymidine transport by ≥ 89% in all tested cell lines.
- Thymidine completely prevented growth inhibition at the MTA IC50 in all cell lines.
- Both thymidine and hypoxanthine were required for complete reversal of growth inhibition.
Takeaway
This study found that a drug called dipyridamole can help another cancer drug work better by stopping cells from using a substance called thymidine.
Methodology
The study tested the effects of dipyridamole on thymidine and hypoxanthine rescue in various human cancer cell lines.
Digital Object Identifier (DOI)
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