Early Autonomic Neuropathy in Crohn's Disease
Author Information
Author(s): Bodil Ohlsson, Göran Sundkvist, Stefan Lindgren
Primary Institution: Lund University
Hypothesis
Is autonomic neuropathy an early manifestation of Crohn's disease?
Conclusion
Patients with Crohn's disease suffer from autonomic neuropathy early in their disease, indicating systemic involvement.
Supporting Evidence
- Patients with Crohn's disease had lower blood pressure after tilt compared to controls.
- The study suggests that autonomic neuropathy is a systemic feature of Crohn's disease.
- The changes in blood pressure were more pronounced after seven years.
Takeaway
This study found that people with Crohn's disease can have nerve problems early on, which can affect many parts of their body.
Methodology
Twenty patients with Crohn's disease were examined for autonomic reflexes and re-evaluated seven years later.
Limitations
Some patients were lost to follow-up, and not all tests were performed at both assessments.
Participant Demographics
Median age 40 years, 14 women, median disease duration 44 months.
Statistical Information
P-Value
p = 0.016, p = 0.042, p = 0.028
Confidence Interval
95% confidence interval
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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