A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis
2008
The Role of PPARβ/δ in Tumor Stroma and Tumorigenesis
publication
Evidence: moderate
Author Information
Author(s): Rolf Müller, Martin Kömhoff, Jeffrey M. Peters, Sabine Müller-Brüsselbach
Primary Institution: Institute of Molecular Biology and Tumor Research (IMT), Philipps-University
Hypothesis
What is the role of PPARβ/δ in tumor stroma and tumorigenesis?
Conclusion
PPARβ/δ is essential for the proper formation and maintenance of tumor blood vessels.
Supporting Evidence
- PPARβ/δ regulates tumor endothelial cell proliferation.
- Without PPARβ/δ, tumors show abnormal blood vessel structures.
- PPARβ/δ is crucial for the differentiation of endothelial cells in tumors.
Takeaway
PPARβ/δ helps tumors grow by making sure they have the right blood vessels. Without it, the blood vessels can become messed up.
Methodology
The review summarizes findings from various studies on PPARβ/δ's role in tumor growth and vascularization.
Limitations
The review does not provide new experimental data but summarizes existing literature.
Digital Object Identifier (DOI)
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