Natural Serine Proteases and Their Role in Fighting Amyloid Formation
Author Information
Author(s): Metkar Sanjay Kisan, Udayakumar Saranya, Girigoswami Agnishwar, Girigoswami Koyeli
Primary Institution: Chettinad Hospital and Research Institute
Hypothesis
Can serine proteases effectively inhibit amyloid aggregation associated with neurodegenerative diseases?
Conclusion
Serine proteases have potential applications in treating amyloidosis by inhibiting amyloid aggregate formation.
Supporting Evidence
- Serine proteases can degrade amyloid aggregates in vitro.
- Lumbrokinase and serratiopeptidase have shown promise in amyloid degradation.
- Nattokinase has been effective in reducing amyloid fibrils at physiological conditions.
- Keratinase can degrade prion proteins, which are resistant to other proteases.
Takeaway
This study talks about special proteins called serine proteases that can help break down harmful clumps in the brain that cause diseases like Alzheimer's.
Methodology
The authors reviewed relevant articles from the past 10 years using databases like Google Scholar, PubMed, and Scopus.
Limitations
The review is based on existing literature and may not include all recent findings.
Digital Object Identifier (DOI)
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