Increased sensitivity to TRAIL-induced apoptosis occurs during the adenoma to carcinoma transition of colorectal carcinogenesis
2005
Increased sensitivity to TRAIL-induced apoptosis during colorectal cancer progression
Sample size: 7
publication
Evidence: high
Author Information
Author(s): Hague A, Hicks D J, Hasan F, Smartt H, Cohen G M, Paraskeva C, MacFarlane M
Primary Institution: University of Bristol
Hypothesis
Does sensitivity to TRAIL-induced apoptosis increase during the adenoma to carcinoma transition in colorectal cancer?
Conclusion
Colorectal carcinoma cells are significantly more sensitive to TRAIL-induced apoptosis than premalignant adenoma cells.
Supporting Evidence
- Carcinoma cell lines were significantly more sensitive to TRAIL than adenoma cell lines.
- TRAIL sensitivity increased during the conversion of adenoma cells to a malignant phenotype.
- Cell surface receptor expression did not correlate with TRAIL sensitivity.
Takeaway
This study found that cancer cells are better at dying when treated with a special protein called TRAIL compared to early-stage tumor cells.
Methodology
The study compared TRAIL-induced apoptosis in four adenoma and three carcinoma cell lines under the same culture conditions.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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