Comments on Ototoxicity of Cisplatinum in Children
Author Information
Author(s): P. Brock, S. Bellman
Primary Institution: University Hospital Gasthuisberg, The Hospital for Sick Children
Conclusion
The authors argue that the assessment methods used in the original study may underestimate the severity of hearing loss in children treated with cisplatinum.
Supporting Evidence
- The authors believe that a change of hearing threshold of 15 dB or more should be considered significant in clinical settings.
- They argue that the maximum hearing loss method used in the original study may exaggerate the severity of hearing disability.
- The authors found no evidence of recovery in seven patients followed for at least five years.
Takeaway
The way we measure hearing loss in kids getting cisplatinum might not show how bad it really is, and some kids might not even notice they have a problem.
Methodology
The authors critique the statistical methods used in a previous study and suggest alternative methods for assessing hearing loss.
Potential Biases
The authors suggest that the original study may have biases in how hearing loss was measured.
Limitations
The commentary is based on a small sample size and may not represent all children treated with cisplatinum.
Participant Demographics
Children treated with cisplatinum, with a focus on those experiencing hearing loss.
Want to read the original?
Access the complete publication on the publisher's website