Comparing Genotype-Expression Analysis Methods
Author Information
Author(s): Suh Young Ju, Lee Hye-Soon, Batliwalla Franak, Li Wentian
Primary Institution: Ewha Womans University
Hypothesis
Does the use of only founders versus all pedigree members in genotype-expression association analysis affect the results?
Conclusion
Using all pedigree members in genotype-expression association analyses can yield different results compared to using only founders.
Supporting Evidence
- Using all pedigree members can increase sample size and check consistency among samples.
- Significant associations may change when comparing results from founders only to all members.
- Age dependence in expression levels was observed in several eQTs.
Takeaway
This study looks at how using different groups of people can change the results when studying how genes affect traits.
Methodology
Linear regression and mixed models were used to analyze genotype-expression associations.
Potential Biases
Using only founders may lead to biased results if they are not representative of the entire pedigree.
Limitations
The study may not account for all potential biases in sample selection.
Participant Demographics
Participants included founders and their descendants from various pedigrees.
Statistical Information
P-Value
1.4 × 10-6
Statistical Significance
p<0.05
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