Correction: A Systematic Map of Genetic Variation in Plasmodium falciparum
Author Information
Author(s): Claire Kidgell, Sarah Volkman, Johanna Daily, Justin O. Borevitz, David Plouffe, Yingyao Zhou, Jeffrey R. Johnson, Karine G. Roch, Ousmane Ndir, Omar Mboup, Soulyemane Batalov, Dyann F. Wirth, Elizabeth A. Winzeler
Primary Institution: Public Library of Science
Conclusion
The study corrected the labeling of supporting information files and confirmed gene amplifications and deletions in Plasmodium falciparum.
Supporting Evidence
- Only two genes were shared by all Senegal strains examined.
- Quantitative real-time PCR analysis confirmed a probable amplification in 3D7 for GTP cyclohydrolase.
- A total of 33 genes were called 'absent' in at least two out of three hybridizations for each strain.
- No significant differences were observed in the variation within immunogens and protein biosynthesis genes between the two groups of isolates.
Takeaway
The researchers found some genes that change a lot in different strains of malaria, and they fixed some mistakes in their earlier work.
Methodology
The study involved comparing gene variations in different strains of Plasmodium falciparum using quantitative real-time PCR and a custom-designed Affymetrix malaria full-genome array.
Statistical Information
P-Value
6.37E−58
Statistical Significance
p = 6.37E−58
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website