Oral Tegafur for Gastrointestinal Cancers
Author Information
Author(s): S. Palmeri, V. Gebbia, A. Russo, M.G. Armata, N. Gebbia, L. Rausa
Primary Institution: Istituto di Farmacologia, Universitai di Palermo
Hypothesis
Is oral tegafur effective in treating gastrointestinal tract cancers?
Conclusion
Oral tegafur is effective for stomach and colorectal cancers but does not significantly improve survival.
Supporting Evidence
- 17% of evaluable patients showed a partial response.
- 55% of patients progressed without response.
- Oral tegafur was well tolerated with mild side effects.
Takeaway
Doctors gave a medicine called tegafur to people with stomach and bowel cancer to see if it helped them feel better. Some people got better, but it didn't help everyone live longer.
Methodology
Fifty patients with advanced gastrointestinal tract cancer were treated with oral tegafur and monitored for response and toxicity.
Limitations
The study had a small sample size and lacked a control group.
Participant Demographics
31 males (62%) and 19 females (38%), mean age 62 years.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
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