HOXB13 as a Marker of Prostate Cancer
Author Information
Author(s): Edwards S, Campbell C, Flohr P, Shipley J, Giddings I, te-Poele R, Dodson A, Foster C, Clark J, Jhavar S, Kovacs G, Cooper C S
Primary Institution: Institute of Cancer Research
Hypothesis
Can expression analysis identify novel markers of human prostate cancer?
Conclusion
The study identified HOXB13 as a potential new marker for prostate cancer through expression analysis.
Supporting Evidence
- HOXB13 was significantly overexpressed in prostate cancer compared to normal adjacent prostate tissue.
- Ten established prostate cancer markers were identified alongside HOXB13.
- Quantitative RT–PCR confirmed the expression of HOXB13 in all prostate cancer specimens.
Takeaway
Researchers looked at genes in prostate cancer and found that HOXB13 is a good marker to help identify the disease.
Methodology
Expression analysis using microarrays of randomly selected cDNA clones from the LNCaP prostate cancer cell line.
Limitations
The study may not have identified all potential markers due to the limited number of clones selected.
Participant Demographics
Included 37 primary prostate cancer specimens and 20 normal prostates.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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