Genome-Wide Association Study Identifies Four Loci Associated with Eruption of Permanent Teeth
Author Information
Author(s): Geller Frank, Feenstra Bjarke, Zhang Hao, Shaffer John R., Hansen Thomas, Esserlind Ann-Louise, Boyd Heather A., Nohr Ellen A., Timpson Nicholas J., Fatemifar Ghazaleh, Paternoster Lavinia, Evans David M., Weyant Robert J., Levy Steven M., Lathrop Mark, Smith George Davey, Murray Jeffrey C., Olesen Jes, Werge Thomas, Marazita Mary L., Sørensen Thorkild I. A., Melbye Mads
Primary Institution: Statens Serum Institut, Copenhagen, Denmark
Hypothesis
What genetic factors influence the timing of permanent tooth eruption in children?
Conclusion
The study identified four genetic loci associated with the timing of permanent tooth eruption in children.
Supporting Evidence
- The study analyzed data from over 5,100 women and replicated findings in an additional 3,762 individuals.
- Four loci were identified with genome-wide significance for the timing of permanent tooth eruption.
- Two of the loci were previously associated with primary tooth eruption.
- The combined effect of the four genetic variants was most pronounced between ages 10 and 12.
Takeaway
Scientists found four specific genes that can affect when kids get their permanent teeth, which can help understand dental health better.
Methodology
The study conducted a genome-wide association study (GWAS) analyzing dental records and genetic data from over 5,100 women and replicated findings in an additional 3,762 individuals.
Limitations
The study lacked corresponding data on primary dentition and other growth traits, which were not collected during dental visits.
Participant Demographics
Participants were primarily women from the Danish National Birth Cohort, with additional samples from the US and Denmark.
Statistical Information
P-Value
P<10−11
Confidence Interval
95% confidence interval: 2.9–4.1
Statistical Significance
p<5×10−8
Digital Object Identifier (DOI)
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