Induction of cell cycle changes and modulation of apoptogenic/anti-apoptotic and extracellular signaling regulatory protein expression by water extracts of I'm-Yunity™ (PSP)
2006
Effects of I'm-Yunity™ (PSP) on Cancer Cells
publication
Evidence: moderate
Author Information
Author(s): Hsieh Tze-chen, Wu Peili, Park Spencer, Wu Joseph M
Primary Institution: New York Medical College
Hypothesis
How does I'm-Yunity™ (PSP) affect cell cycle and apoptosis in human leukemia cells?
Conclusion
I'm-Yunity™ (PSP) induces cell cycle arrest and alters protein expression related to apoptosis in leukemia cells, leading to reduced proliferation and increased apoptosis.
Supporting Evidence
- I'm-Yunity™ (PSP) inhibited cell proliferation in HL-60 and U-937 cells.
- The treatment caused cell cycle arrest in the G1/S and G2/M phases.
- There was a decrease in anti-apoptotic proteins and an increase in apoptogenic proteins in treated cells.
- NF-κB expression was reduced in I'm-Yunity™ (PSP)-treated cells.
Takeaway
I'm-Yunity™ (PSP) is a mushroom extract that helps stop cancer cells from growing and makes them die by changing how they work inside.
Methodology
Human leukemia HL-60 and U-937 cells were treated with aqueous extracts of I'm-Yunity™ (PSP) and analyzed for cell proliferation, viability, cell cycle phase transition, and protein expression.
Digital Object Identifier (DOI)
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