N′-[1-(2,4-Dioxo-3,4-dihydro-2H-1-benzopyran-3-ylidene)ethyl]thiophene-2-carbohydrazide
2011
New Compound from Benzopyran and Thiophene
publication
Evidence: moderate
Author Information
Author(s): Helliwell Madeleine, Nasiopoulou Despina A., Harris Philip A., Kotali Antigoni, Joule John A.
Primary Institution: The School of Chemistry, The University of Manchester
Hypothesis
The reaction of 3-acetyl-4-hydroxycoumarin with thien-2-ylcarboxylic acid hydrazide will yield a specific hydrazone compound.
Conclusion
The study confirmed the formation of a new compound with a specific tautomeric form through X-ray determination.
Supporting Evidence
- The compound was obtained with a yield of 94%.
- The molecular conformation is stabilized by an intramolecular hydrogen bond.
- Intermolecular hydrogen bonds link the molecules into chains along the crystal structure.
Takeaway
Scientists mixed two chemicals to create a new compound, and they used special imaging to see how it looks.
Methodology
The compound was synthesized by heating a mixture of 3-acetyl-4-hydroxycoumarin and thien-2-ylcarboxylic acid hydrazide in propan-1-ol.
Digital Object Identifier (DOI)
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