Genetic Factors Affecting Kidney Function in African Americans
Author Information
Author(s): Liu Ching-Ti, Garnaas Maija K., Tin Adrienne, Kottgen Anna, Franceschini Nora, Peralta Carmen A., de Boer Ian H., Lu Xiaoning, Atkinson Elizabeth, Ding Jingzhong, Nalls Michael, Shriner Daniel, Coresh Josef, Kutlar Abdullah, Bibbins-Domingo Kirsten, Siscovick David, Akylbekova Ermeg, Wyatt Sharon, Astor Brad, Mychaleckjy Josef, Li Man, Reilly Muredach P., Townsend Raymond R., Adeyemo Adebowale, Zonderman Alan B., de Andrade Mariza, Turner Stephen T., Mosley Thomas H., Harris Tamara B., The CKDGen Consortium, Rotimi Charles N., Liu Yongmei, Kardia Sharon L. R., Evans Michele K., Shlipak Michael G., Kramer Holly, Flessner Michael F., Dreisbach Albert W., Goessling Wolfram, Cupples L. Adrienne, Kao W. Linda, Fox Caroline S.
Primary Institution: Boston University School of Public Health
Hypothesis
What genetic loci are associated with renal function in African Americans?
Conclusion
The study identified several SNPs associated with kidney function in African Americans, including three suggestive loci for UACR and eGFR.
Supporting Evidence
- 23 of 24 previously identified SNPs had direction-consistent associations with eGFR in African Americans.
- 2 SNPs achieved nominal significance in the study.
- Functional studies in zebrafish supported the role of kcnq1 in kidney development.
Takeaway
Researchers looked at genes that might affect kidney health in African Americans and found some important ones that could help us understand kidney disease better.
Methodology
The study used genome-wide association studies (GWAS) and candidate-gene SNP association analyses in African Americans.
Potential Biases
Potential bias due to the reliance on single-point measurements for serum creatinine and albuminuria.
Limitations
The study's sample size for discovery and replication was relatively modest, which may limit the strength of the findings.
Participant Demographics
Participants were primarily African Americans, with a sample size of 8110.
Statistical Information
P-Value
p<5.0*10−6
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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