NAP and D-SAL: neuroprotection against the β amyloid peptide (1–42)
2008
Neuroprotection Against Alzheimer's Toxic Peptide
publication
Evidence: moderate
Author Information
Author(s): Gozes Illana, Divinski Inna, Piltzer Inbar
Primary Institution: Sackler School of Medicine, Tel Aviv University
Hypothesis
Can NAP and D-SAL protect neurons from the toxic effects of β amyloid peptide (1–42)?
Conclusion
NAP and D-SAL protect cerebral cortical neurons against the major Alzheimer's disease toxic peptide β amyloid (1–42).
Supporting Evidence
- NAP and D-SAL were found to protect against neurotoxicity associated with β amyloid peptide (1–42).
- Maximal protection was observed at concentrations of 10-15 to 10-10 mol/l.
- Bioavailability studies indicated that NAP penetrates cells and crosses the blood-brain barrier.
Takeaway
This study shows that two peptides, NAP and D-SAL, can help protect brain cells from a harmful substance related to Alzheimer's disease.
Methodology
Cerebral cortical cultures derived from newborn rats were used in neuronal survival assays to test the activity of both NAP and D-SAL against β amyloid (1–42).
Participant Demographics
Cerebral cortical cultures derived from newborn rats.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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