Age at Diagnosis Affects Contralateral Breast Cancer Risk in BRCA1 Patients
Author Information
Author(s): Verhoog L C, Brekelmans C T M, Seynaeve C, Meijers-Heijboer E J, Klijn J G M
Primary Institution: Family Cancer Clinic, Department of Medical Oncology, Daniel den Hoed Cancer Centre, University Hospital Rotterdam
Hypothesis
The age at onset of breast cancer influences the risk of developing contralateral breast cancer in BRCA1 mutation carriers.
Conclusion
Younger patients diagnosed with breast cancer have a higher risk of developing contralateral breast cancer compared to older patients.
Supporting Evidence
- 40% of BRCA1 patients diagnosed with breast cancer under 50 developed contralateral breast cancer.
- 12% of patients diagnosed over 50 developed contralateral breast cancer.
- The study involved 164 patients from 83 families.
Takeaway
If someone with a BRCA1 mutation gets breast cancer at a young age, they are more likely to get cancer in the other breast later on.
Methodology
The study analyzed contralateral breast cancer risk in 164 BRCA1 mutation carriers based on the age at diagnosis of their first breast cancer.
Participant Demographics
Patients from 83 families with a proven BRCA1 mutation.
Statistical Information
P-Value
0.02
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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