The STEP-HI Study: Recruitment, Adherence, and Results
Author Information
Author(s): Ellen Binder, Sarah Berry, Jenna Bartley, Robin Marcus, Christine McDonough, Dominic Reeds, Jay Magaziner, Kenneth Schechtman
Primary Institution: Washington University School of Medicine
Hypothesis
Does testosterone replacement therapy improve walking distance in older women with hip fractures compared to exercise alone?
Conclusion
Testosterone replacement therapy does not improve walking distance more than exercise alone in older women with recent hip fractures.
Supporting Evidence
- 4695 chart reviews were completed to identify eligible patients.
- 207 women consented for screening, and 153 were eligible for the study.
- 129 women were randomized to study groups, with 122 included in the intention-to-treat analyses.
- Women in the EX+T group achieved a mean serum testosterone level of 170.1 ng/dL.
Takeaway
This study looked at older women who broke their hips and found that adding testosterone to their exercise didn't help them walk better than just exercising alone.
Methodology
Women aged ≥65 with recent hip fractures were assigned to exercise plus testosterone, exercise plus placebo, or Enhanced Usual Care for 6 months.
Limitations
The changes in walking distance did not differ significantly between the groups.
Participant Demographics
Mean age of participants was 79.3 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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