Carboplatin and renal function in children
1991
Carboplatin and Renal Function in Children
Sample size: 34
publication
Evidence: moderate
Author Information
Author(s): M.C.G. Stevens, I.J. Lewis, A.J. Pearson, C.R. Pinkerton
Primary Institution: The Children's Hospital
Hypothesis
Does carboplatin treatment affect renal function in children with neuroblastoma?
Conclusion
The study suggests that there is little risk of significant early deterioration in renal function in children receiving carboplatin.
Supporting Evidence
- Thirty patients were eligible for toxicity assessment.
- The median change in GFR was +1% after two courses and +9% after four courses.
- Three out of 19 patients showed a greater than 20% fall in GFR after two courses.
- Pre-treatment renal function significantly affected subsequent myelosuppression.
Takeaway
Doctors are studying how a cancer drug called carboplatin affects kids' kidneys, and it looks like it doesn't hurt them much.
Methodology
A phase II study assessed renal function in children with relapsed neuroblastoma receiving carboplatin.
Limitations
Further data are required to explore cumulative nephrotoxicity in children.
Participant Demographics
Children with relapsed or resistant neuroblastoma.
Statistical Information
P-Value
0.05
Statistical Significance
p=0.05
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