Inflammation and Diet in Advanced Cancer Patients
Author Information
Author(s): Amano Koji, Koshimoto Saori, Okamura Satomi, Sakaguchi Tatsuma, Arakawa Sayaka, Matsuda Yoshinobu, Tokoro Akihiro, Takeuchi Takashi, Satomi Eriko, Wada Tamiki, Wada Makoto, Yamada Tomomi, Mori Naoharu
Primary Institution: Osaka International Cancer Institute
Hypothesis
This study aimed to determine associations between the CRP level and dietary intake, symptoms, and eating-related distress (ERD).
Conclusion
High CRP levels were significantly associated with reduced dietary intake, appetite loss, and ERD.
Supporting Evidence
- The high CRP group had a more reduced dietary intake (p = 0.002).
- The high CRP group had significantly higher risks for ERD (odds ratio [OR] 2.13, 95% CI 1.10–4.11).
- Patients with high CRP levels had significantly more impaired performance status and higher weight loss rates.
Takeaway
Patients with high levels of a protein called CRP eat less and feel more upset about food, which can be a sign they need special care.
Methodology
A multicenter survey was conducted among advanced cancer patients using questionnaires to assess dietary intake, symptoms, and distress.
Potential Biases
Potential biases due to self-reported data and exclusion of patients in serious psychological distress.
Limitations
Results may not be generalizable beyond Japanese inpatients, and CRP levels can be influenced by factors other than cancer cachexia.
Participant Demographics
Median age was 67 years, with slightly more females (52.1%) than males (47.9%).
Statistical Information
P-Value
0.002
Confidence Interval
95% CI 1.10–4.11
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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