Platelet-activating factor mediates trinitrobenzene induced dysmotility in the left colon
Author Information
Author(s): W. E. Longo, J. Standeven, B. Chandel, Y. Deshpande, A. M. Vernava, D. Kaminski
Primary Institution: The Surgical Research Institute, St Louis University School of Medicine
Hypothesis
Does TNB alter colonic tissue levels of PAF and affect colonic motility?
Conclusion
TNB increases tissue levels of PAF and alters colonic motility, but pretreatment with a PAF antagonist can mitigate these effects.
Supporting Evidence
- TNB administration increased tissue levels of PAF and the average force of colonic contractions.
- WEB-2170 pretreatment decreased tissue concentrations of PAF and improved motility parameters.
- Colonic inflammation and dysmotility were induced in the isolated rabbit colon model.
Takeaway
When a substance called TNB is introduced to the colon, it makes the colon work differently by increasing a chemical called PAF, but using a special blocker can help fix this.
Methodology
The study involved isolating the rabbit colon, inducing inflammation with TNB, and measuring motility using strain gauge transducers.
Participant Demographics
Isolated rabbit colon
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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