Cannabinoid inhibition of mechanosensitive K+ channels
2024
Cannabinoid Inhibition of Mechanosensitive K+ Channels
publication
Author Information
Author(s): Docter Trevor, Sorum Ben, Deshmane Rahul, Doubravsky Cody, Brohawn Stephen G
Primary Institution: Cold Spring Harbor Laboratory
Hypothesis
Cannabinoids inhibit mechanosensitive K+ channels, affecting spike propagation in myelinated axons.
Conclusion
Cannabinoids, including CBD, inhibit mechanosensitive K+ channels, which may help in conditions caused by TRAAK mutations.
Supporting Evidence
- CBD and other cannabinoids are potent inhibitors of mechanosensitive K+ channels.
- Five TRAAK mutations that cause epilepsy retain sensitivity to cannabinoid inhibition.
- A cryo-EM structure reveals CBD binds in the intracellular cavity of TREK-1.
Takeaway
Cannabinoids can block certain channels in nerve cells, which might help treat some types of epilepsy.
Methodology
Cryo-EM structure analysis and functional assays on K2P channels.
Digital Object Identifier (DOI)
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