Precision Oncology Approach for Urachal Carcinoma: A Clinical Case Report
Author Information
Author(s): Juhász Dániel, Csizmarik Anita, Szalontai János, Keszthelyi Attila, Dér Bálint, Kubik András, Szűcs Miklós, Kenessey István, Ertl Iris E., Berger Walter, Englinger Bernhard, Shariat Shahrokh F., Nyirády Péter, Szarvas Tibor
Primary Institution: Semmelweis University
Hypothesis
Can a molecularly informed precision oncology approach improve treatment outcomes for patients with urachal carcinoma?
Conclusion
The case demonstrates that while urachal carcinoma is aggressive, a combination of surgical and systemic therapies can control the disease for a period, but challenges remain in treatment selection due to limited options.
Supporting Evidence
- The patient underwent intensive therapy with three surgeries and five lines of systemic treatments.
- Next-generation sequencing analysis was performed on patient-derived tumor cells.
- Serum carcinoembryonic antigen (CEA) levels were monitored throughout the treatment.
Takeaway
This study is about a woman with a rare type of cancer who tried many treatments, but the cancer kept coming back, showing that it's hard to treat.
Methodology
The patient underwent multiple surgeries and systemic treatments, including chemotherapy and targeted therapies, with next-generation sequencing and drug screening performed on tumor cells.
Limitations
The study is based on a single case, limiting the generalizability of the findings.
Participant Demographics
A 31-year-old female patient with urachal carcinoma.
Digital Object Identifier (DOI)
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