Effectiveness of Purple Leaves and Hydroxyapatite for Bone Preservation
Author Information
Author(s): Sitalaksmi Ratri Maya, Azharpratomo Rizkipriyanto, Irsan Shafira Ninditya, Rahmania Primanda Nur, Wati Sisca Meida, Adam Syafira Salsabila, Bilbalqish Kavanila, Shariff Khairul Anuar bin, Laksono Harry, Dahlan Agus, Rianti Devi
Primary Institution: Universitas Airlangga, Indonesia
Hypothesis
Does the combination of purple leaves extract and hydroxyapatite enhance bone regeneration?
Conclusion
The combination of purple leaves extract and hydroxyapatite significantly enhances the expression of key osteogenic markers and calcium deposition.
Supporting Evidence
- The combination of purple leaves and hydroxyapatite significantly increased RUNX2, OSX, OPN, ALP expression and calcium deposition.
- Hydroxyapatite is known for its biocompatibility and ability to induce osteoblast differentiation.
- Purple leaves contain compounds that have antimicrobial and anti-inflammatory properties.
Takeaway
Using purple leaves and hydroxyapatite together helps bones heal better after a tooth is pulled.
Methodology
The study used MTT Assay, ICC, and Alizarin Red staining to evaluate the effects of different concentrations of purple leaves extract and hydroxyapatite on stem cells over 21 days.
Limitations
The study was conducted in vitro, and the long-term effects in vivo are still unknown.
Participant Demographics
Adipose Stem Cells were isolated from young male rabbits.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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