Chlamydial Infection and Rheumatoid Arthritis Development
Author Information
Author(s): Lamacchia Celine, Aymon Romain, Hattel Brian C, Aeby Sebastien, Kebbi-Beghdadi Carole, Gilbert Benoit, Studer Olivia, Norris Jill M, Nolers V Michael, Demoruelle M Kristen, Feser Marie L, Moss Laura Kay, Courvoisier Delphine S, Lauper Kim, Deane Kevin D, Greub Gilbert, Finckh Axel
Primary Institution: Geneva University Hospital and Faculty of Medicine, University of Geneva
Hypothesis
Is there a relationship between chlamydial infection and the development of rheumatoid arthritis (RA) autoimmunity?
Conclusion
Self-reported chlamydial infections are associated with elevated RA autoimmunity in at-risk individuals.
Supporting Evidence
- Among 1231 RA-FDRs, 168 (13.6%) developed RA autoimmunity.
- Prevalence of self-reported chlamydial infection was significantly higher in individuals with RA autoimmunity compared with controls (17.9% vs 9.8%).
- The association remained significant after adjustments with an odds ratio of 1.91.
- Stronger effect sizes were observed in later stages of RA development.
- Similar trends were observed in a replication cohort in the USA.
Takeaway
People who had chlamydia infections might be more likely to develop a condition that can lead to rheumatoid arthritis, especially if they have family members with the disease.
Methodology
This study analyzed self-reported chlamydial infections and serological evidence in a cohort of first-degree relatives of RA patients.
Potential Biases
Response bias may occur if participants are aware of their chlamydial infection status when answering the questionnaire.
Limitations
The study may have false-positive serology results and relies on self-reported data, which can be biased.
Participant Demographics
The cohort included 1231 first-degree relatives of RA patients, predominantly women (75.6%) with a mean age of 49.8 years.
Statistical Information
P-Value
p<0.01
Confidence Interval
95% CI: 1.20, 2.95
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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