The Role of ATRX in Mammalian Sexual Differentiation
Author Information
Author(s): Huyhn Kim, Renfree Marilyn B, Graves Jennifer A, Pask Andrew J
Primary Institution: ARC Centre of Excellence for Kangaroo Genomics
Hypothesis
What is the role of ATRX in gonadal development in mammals?
Conclusion
ATRX plays a critical and conserved role in the development of the testis and ovary in mammals.
Supporting Evidence
- ATRX and ATRY were strongly expressed in the developing male and female gonads respectively.
- ATRX expression was detected in various tissues including limbs and craniofacial elements.
- The expression profile of ATRX overlaps with that of DMRT1, suggesting a link in gonadal development.
Takeaway
ATRX is a gene that helps determine how male and female reproductive organs develop in mammals, and it has been around for a very long time.
Methodology
The study examined ATRX and ATRY expression during early development and gonadogenesis in tammar wallabies and mice using in situ hybridization and immunohistochemistry.
Limitations
The study primarily focuses on two species, which may limit the generalizability of the findings to other mammals.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website