Comparing Antibiotics for Treating Chlamydia in Pregnant Women
Author Information
Author(s): Mark A. Turrentine, Lisa Troyer, Bernard Gonik
Primary Institution: University of Texas Health Science Center--Houston
Hypothesis
The study aims to compare the efficacy and side effects of erythromycin, amoxicillin, and clindamycin in eradicating Chlamydia trachomatis from pregnant women.
Conclusion
All three antibiotics are effective for treating Chlamydia in pregnant women, but erythromycin has more side effects.
Supporting Evidence
- All three medications were effective agents for the treatment of antenatal C. trachomatis infection.
- Erythromycin had a higher incidence of side effects compared to amoxicillin and clindamycin.
- Amoxicillin and clindamycin are reasonable alternatives for patients unable to tolerate erythromycin.
Takeaway
Doctors tested three different medicines to see which works best for pregnant women with a certain infection, and they found that all three work well, but one makes people feel sick more often.
Methodology
The study enrolled 174 women with positive cervical cultures for C. trachomatis and randomly assigned them to receive one of three antibiotics.
Potential Biases
Potential bias due to self-reported adherence to medication and partner treatment.
Limitations
The study had a small sample size and some patients were lost to follow-up.
Participant Demographics
Women under 36 weeks gestation with positive cervical cultures for C. trachomatis.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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