C-myc amplification in breast cancer: a meta-analysis of its occurrence and prognostic relevance
2000
C-myc Amplification in Breast Cancer
Sample size: 29
publication
Evidence: moderate
Author Information
Author(s): Deming S L, Nass S J, Dickson R B, Trock B J
Primary Institution: Georgetown University
Hypothesis
What is the frequency and prognostic relevance of c-myc amplification in breast cancer?
Conclusion
C-myc amplification is relatively common in breast cancer and may provide independent prognostic information.
Supporting Evidence
- The weighted average frequency of c-myc amplification in breast tumours was 15.7%.
- C-myc amplification exhibited significant but weak associations with tumour grade, lymph-node metastasis, negative progesterone receptor status, and postmenopausal status.
- Amplification was significantly associated with risk of relapse and death.
Takeaway
Scientists looked at many studies to see how often a certain gene is changed in breast cancer, and they found it happens a lot and can help predict how serious the cancer is.
Methodology
A comprehensive literature search and meta-analysis were conducted evaluating 29 studies.
Limitations
More rigorous studies with consistent methodology are required to validate this association.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% CI = 12.5–18.8%
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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