Peptide P111-136 Inhibits Prostate Cancer Growth
Author Information
Author(s): Hamma-Kourbali Yamina, Bermek Oya, Bernard-Pierrot Isabelle, Karaky Racha, Martel-Renoir Dominique, Frechault Sophie, Courty José, Delbé Jean
Primary Institution: Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires (CRRET), Université Paris Est Créteil, CNRS
Hypothesis
Can the synthetic peptide P111-136 inhibit the growth of prostate cancer PC-3 cells?
Conclusion
P111-136 significantly inhibits the growth of PC-3 cells and associated angiogenesis in vivo.
Supporting Evidence
- P111-136 inhibits colony formation of PC-3 cells in vitro.
- P111-136 treatment reduced tumor size by 61% in mice after 25 days.
- Treatment with P111-136 increased apoptosis in tumor cells.
- P111-136 significantly decreased endothelial-cell density in tumors.
Takeaway
A special peptide can stop prostate cancer cells from growing and also prevent new blood vessels from forming in tumors.
Methodology
The study involved in vitro and in vivo experiments, including colony formation assays and xenograft models in mice.
Participant Demographics
Female athymic nude mice were used for in vivo experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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