Mutagenic Activity of Indigofera truxillensis and I. suffruticosa
Author Information
Author(s): Tamara Regina Calvo, Cássia Regina Primila Cardoso, Adriana Candido da Silva Moura, Lourdes Campaner dos Santos, Ilce Mara Syllos Colus, Wagner Vilegas, Eliana Aparecida Varanda
Primary Institution: UNESP-São Paulo State University
Hypothesis
The study investigates the mutagenic activity of methanolic extracts and fractions of Indigofera truxillensis and I. suffruticosa.
Conclusion
The methanol extract of I. truxillensis showed mutagenic activity, particularly in the TA98 strain, while the flavonoid and alkaloid fractions also exhibited mutagenicity.
Supporting Evidence
- The methanolic extract of I. truxillensis showed mutagenic activity in the TA98 strain without S9.
- The flavonoid and alkaloid fractions of both plants showed mutagenicity.
- Indigo was found mainly responsible for the mutagenic activity.
Takeaway
This study looked at two plants to see if they could change DNA in a bad way. One plant did show it could cause changes, which might be harmful.
Methodology
The mutagenic activity was evaluated using Salmonella/microsome assays with various strains.
Limitations
The study does not provide extensive data on the long-term effects or safety of using these plants.
Statistical Information
P-Value
p ≤ 0.05
Statistical Significance
p ≤ 0.05
Digital Object Identifier (DOI)
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