Dysfunctional Endothelial Progenitor Cells in Metabolic Syndrome
Author Information
Author(s): Devaraj Sridevi, Ishwarlal Jialal
Primary Institution: UC Davis Medical Center and the VA Medical Center
Hypothesis
EPC number and/or functionality could serve as a novel cellular biomarker of endothelial dysfunction and cardiovascular disease risk in metabolic syndrome.
Conclusion
EPC number and functionality are impaired in patients with metabolic syndrome, which may indicate increased cardiovascular risk.
Supporting Evidence
- EPC number and functionality are significantly reduced in metabolic syndrome patients.
- Patients with metabolic syndrome show impaired endothelial function.
- CD34+KDR+ cells are independent predictors of cardiovascular outcomes.
Takeaway
People with metabolic syndrome have fewer healthy cells that help repair blood vessels, which can lead to heart problems.
Methodology
The study assessed EPC number and functionality in subjects with metabolic syndrome and matched controls.
Potential Biases
Potential bias due to the exclusion of patients with comorbidities.
Limitations
The study did not include patients with diabetes or cardiovascular disease, which may limit the generalizability of the findings.
Participant Demographics
77% of participants with metabolic syndrome were female.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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