Detecting Group B Streptococcus in High-Risk Pregnancies
Author Information
Author(s): Mara J. Dinsmoor, Harry P. Dalton, Thomas C.C. Peng, James T. Christmas, Sousan Sayahtaheri-Altaie, Kevin Harvey, J. Peter VanDorsten
Primary Institution: Medical College of Virginia Commonwealth University
Hypothesis
The study aims to evaluate the Equate Strep B test for clinical use in patients at high risk for complications from group B streptococcus disease.
Conclusion
The Equate rapid assay is not a sensitive method for detecting GBS in high-risk patients.
Supporting Evidence
- 24% of patients were colonized with GBS.
- The sensitivity of the rapid assay was only 28%.
- The specificity of the rapid assay was 84%.
- Patients with ruptured membranes had a higher prevalence of GBS.
- Only 55-67% of patients with positive antepartum cultures had positive cultures at labor.
Takeaway
The test used to find a germ that can make babies sick isn't very good, especially for pregnant women who are at risk.
Methodology
Vaginoperineal swabs were taken from patients, and both culture and Equate assay were performed to detect GBS.
Limitations
The sensitivity of the rapid assay was low, and it may not be suitable for routine clinical use.
Participant Demographics
Mean age of participants was 24.6 years, with a mean gestational age of 32.2 weeks; 35% were nulliparous.
Statistical Information
P-Value
0.004
Statistical Significance
p<0.05
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