A Role for Peroxisome Proliferator-Activated Receptors in the Immunopathology of Schistosomiasis?
2012
The Role of PPARs in Schistosomiasis
publication
Evidence: moderate
Author Information
Author(s): Anthony Barrie J., Allen Jeremy T., Li Yuesheng S., McManus Donald P.
Primary Institution: Queensland Institute of Medical Research
Hypothesis
PPARs may play a role in the modulation of the immune response in schistosomiasis.
Conclusion
PPARs are involved in regulating the immune response to schistosomiasis and may serve as therapeutic targets.
Supporting Evidence
- PPARs are anti-inflammatory and promote Th2 type responses.
- Helminth infections like schistosomiasis are characterized by a Th2 response.
- PPARs could be involved in the alternative activation of macrophages.
Takeaway
PPARs help our body fight off schistosomiasis by changing how our immune system works, making it less aggressive and more balanced.
Digital Object Identifier (DOI)
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