A KETOGENIC DIET REDUCES AGE-INDUCED CHRONIC NEUROINFLAMMATION IN MICE
2024
Ketogenic Diet Reduces Inflammation in Aging Mice
publication
Author Information
Author(s): Nomura Mitsunori, Newman John
Primary Institution: Buck Institute for Research on Aging
Hypothesis
Does beta-hydroxybutyrate (BHB) affect brain cells transcriptionally and reduce neuroinflammation in aging mice?
Conclusion
BHB mitigates the microglial response to inflammatory stimuli, potentially decreasing chronic inflammation in the brain after long-term ketogenic diet treatment in aging mice.
Supporting Evidence
- BHB reduces midlife mortality and improves memory in aging mice.
- BHB inhibits LPS-induced inflammatory gene activation in microglia.
- A one-year cyclic ketogenic diet reduces neuroinflammation induced by aging.
Takeaway
Eating a special diet can help reduce inflammation in the brains of older mice, which might help them stay healthier.
Methodology
Gene expression analysis in primary human brain cells and experiments with aging mice on a ketogenic diet.
Participant Demographics
12-month-old male mice were used in the study.
Digital Object Identifier (DOI)
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