Piroxicam and Delayed Muscle Soreness
Author Information
Author(s): J-L. Croisier, G. Caius, CA T. Monfils, G. Deby-Dupon, M. Fafchamps, I. Venneman, J-M. Crielaard, A. Juchms-Ferir, C. Lhermerout, M. Lamy, C. Deby
Primary Institution: University of Liege
Hypothesis
Delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of prostaglandin E2 (PGE2).
Conclusion
Oral administration of piroxicam fails to reduce muscle damage and DOMS caused by strenuous eccentric exercise.
Supporting Evidence
- The mean plasma concentration of PGE2 was significantly lower in the group treated with piroxicam.
- Maximal soreness was noted 48 hours post-exercise.
- Serum creatine kinase activity and myoglobin concentration increased significantly after exercise.
Takeaway
This study looked at whether a medicine called piroxicam could help with muscle soreness after exercise, but it didn't work.
Methodology
Ten healthy male subjects performed isokinetic tests with either placebo or piroxicam, and muscle soreness and damage were measured.
Limitations
The study only included healthy male subjects, which may limit the generalizability of the results.
Participant Demographics
Ten moderately active, healthy male subjects with a mean age of 22 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
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