annotationTools: A Tool for Gene Expression Studies
Author Information
Author(s): Alexandre Kuhn, Ruth Luthi-Carter, Mauro Delorenzi
Primary Institution: Swiss Institute of Bioinformatics (SIB)
Hypothesis
Can the R package annotationTools effectively integrate and analyze heterogeneous gene expression data across different platforms and species?
Conclusion
The R package annotationTools provides a simple solution to handle microarray annotation and orthology tables, allowing easy integration and analysis of heterogeneous microarray experiments across different technological platforms or species.
Supporting Evidence
- The package allows for the integration of gene expression data from various sources.
- It provides tools for cross-species analysis, which can help in understanding human diseases.
- The package is compliant with Bioconductor standards, ensuring compatibility with other R tools.
Takeaway
The annotationTools package helps scientists compare gene data from different species and technologies easily, making it simpler to understand how genes work across different organisms.
Methodology
The package provides functions to annotate microarray experiments and integrate data from various flat file databases, allowing for cross-species and cross-platform analyses.
Limitations
The package does not address significance testing in comparisons of gene expression data.
Statistical Information
P-Value
6.8E-05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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